Investigators

Investigators Collaborating on MitoSci Med Research
Name Research Image

Laurie S. Kaguni, Director
(BMB)

Our group works in the realm of mitochondrial biogenesis. We pursue the mechanistic enzymology and molecular biology of mitochondrial DNA replication and transcription. We also place a dual emphasis on the development of Drosophila models of mitochondrial function and dysfunction in normal metabolism and disease.

Laurie Kaguni

Shelagh Ferguson-Miller
(BMB)

We apply crystallographic and biochemical methods to studying the process of energy conversion and its regulation, using the mitochondrial model system Rhodobacter sphaeroides and focusing on cytochrome c oxidase.We are also investigating the Rs protein TsPO, homologous to the mitochondrial Peripheral Benzodiazepine Receptor, implicated in apoptosis, response to hypoxia, and steroid and porphyrin transport.

Shelagh Ferguson-Miller

Kathleen A. Gallo
(PSL)

The overall goal of our research is to understand how protein phosphorylation and signaling pathways regulate cellular processes and contribute to diseases, including cancer and neurodegenerative disease. We are integrating biochemical, cellular, and proteomic approaches with animal models to investigate how protein kinases impact mitochondrial function in normal and disease states.

Kathleen A. Gallo

John L. Goudreau
(Neur) (Pharm/Tox)

Our overall goal is to identify targets for neuroprotective therapies for Parkinson's disease(PD) using basic, translational and clinical research approaches. Mitochondrial dysfunction is a central component of PD-related neurodegeneration. We are studying the role of the mitochondrial proteins, parkin and 18 kDa Translocator Protein (TSPO), using in vitro and in vivo pre-clinical models of PD.

John L. Goudreau

John J. LaPres
(BMB)

The LaPres lab is interested in understanding how cells sense changes in oxygen availability and cope with these changes at the metabolic level. More specifically, we study the hypoxia inducible factors (HIFs) and how they regulate mitochondrial function and ultimately determine a cell's fate following exposure to decreased oxygen availability.

John J. LaPres

Kyle E. Miller
(IBIO)

We study the life cycle of mitochondria in neurons using multiple approaches. These include mathematical modeling, biophysical analysis, genetic screens, targeted gene disruption, and behavioral studies in cultured neurons and in Drosophila. Our goal is to develop an overview of the fundamental aspects of mitochondrial biology that will lead to treatments for mitochondrial diseases.

Kyle E. Miller